Drugs and medicine.

ESTROGEN (Estrogenic Substances) Conjugated Estrogens, Esterified Estrogens {Estrone and Equilin)
BRAND NAMES

USA
Amneslrogen (Squibb) Conestrone (Wyeth) Evex (Syntex) Fernogen (Fellows) Genisis (Organon) Menest (Beecham) Menotabs (Fleming) Premarin (Ayerst) SK-Estrogens (Smith Kline
& French)
Theogen (Sig: Pharm.) Formatrix [CD] (Ayerst) Menrium [CD] (Roche) Milprem [CD] (Wallace) PMB-200 [CD] (Ayerst) PMB-400 [CD] (Ayerst)

CANADA
Climestrone (Frosst) Conjugated Estrogens
(Sands)
Menotrol (Squibb) Oestrilin (Desbergers) Premarin (Ayerst) Formatrix [CD] (Ayerst) Menrium [CD] (Roche)

WHAT YOU SHOULD KNOW ABOUT ESTROGENS
Estrogens are female hormones produced by the ovaries. The ovaries make several different kinds of estrogens. In addition, scientists have been able to make a variety of synthetic estrogens. As far as we know, all these estrogens have tne same properties and therefore much the same usefulness, side effects, and risks. This leaflet is intended to help you understand what estrogens are used for, the risks involved in their use, and how to use them as safely as possible.
This leaflet includes the most important information about estrogens, but not all the information. • If you want to know more, you can ask your doctor or pharmacist to let you read the package insert prepared for the doctor.
USES OF ESTROGEN
Estrogens are prescribed by doctors fora number of purposes, including:
1. To provide estrogen during a period of ad
justment when a woman’s ovaries no longer pro
duce it, in order to prevent certain uncomfortable
symptoms of estrogen deficiency. (All women nor
mally stop producing estrogens, generally between
the ages of 45-50; this is called the menopause.)
2. To prevent symptoms of estrogen deficiency
when a woman’s ovaries have been removed sur
gically before the natural menopause.
3. To prevent pregnancy. (Estrogens are given
along with a progestogen, anotherfemale hormone;
these combinations are called oral contraceptives

or birth control pills. Patient labeling is available to women taking oral contraceptives and they will not be discussed in this leaflet.)
4. To treat certain cancers in men (cancer of the
prostate or breast) and in women (certain cancers
of the breast when they occur more than 5 years
after menopause).
5. To prevent painful swelling of the breasts after
pregnancy in women who choose not to nurse
their babies,
THERE IS NO PROPER USE OF ESTROGENS IN A PREGNANT WOMAN.
ESTROGENS IN THE MENOPAUSE
In the natural course of their lives, all women eventually experience a fall in estrogen production. This usually occurs between ages 45 and 50 but may occur earlier or later. Sometimes the ovaries may need to be removed before natural menopause by an operation, producing a “surgical menopause.”
When the amount of estrogen in the blood begins to decrease many women may develop typical symptoms: Feelings of warmth in the face, neck, and chest or sudden intense episodes of heat and sweating throughout the body (called “hot flashes” or “hot flushes”). These symptoms are sometimes very uncomfortable. A few women eventually develop changes in the vagina (called “atrophic vaginitis”) which cause discomfort, especially during intercourse.
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