6. Other effects. Estrogens may cause excess fluid to be retained in the body. This may make some conditions worse, such as epilepsy, migraine, heart disease, or kidney disease.
A spotty darkening of the skin can develop, particularly in the face, and may persist.
SUMMARY
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USA
Amneslrogen (Squibb) Conestrone (Wyeth) Evex (Syntex) Fernogen (Fellows) Genisis (Organon) Menest (Beecham) Menotabs (Fleming) Premarin (Ayerst) SK-Estrogens (Smith Kline
& French)
Theogen (Sig: Pharm.) Formatrix [CD] (Ayerst) Menrium [CD] (Roche) Milprem [CD] (Wallace) PMB-200 [CD] (Ayerst) PMB-400 [CD] (Ayerst)

CANADA
Climestrone (Frosst) Conjugated Estrogens
(Sands)
Menotrol (Squibb) Oestrilin (Desbergers) Premarin (Ayerst) Formatrix [CD] (Ayerst) Menrium [CD] (Roche)

WHAT YOU SHOULD KNOW ABOUT ESTROGENS
Estrogens are female hormones produced by the ovaries. The ovaries make several different kinds of estrogens. In addition, scientists have been able to make a variety of synthetic estrogens. As far as we know, all these estrogens have tne same properties and therefore much the same usefulness, side effects, and risks. This leaflet is intended to help you understand what estrogens are used for, the risks involved in their use, and how to use them as safely as possible.
This leaflet includes the most important information about estrogens, but not all the information. • If you want to know more, you can ask your doctor or pharmacist to let you read the package insert prepared for the doctor.
USES OF ESTROGEN
Estrogens are prescribed by doctors fora number of purposes, including:
1. To provide estrogen during a period of ad
justment when a woman’s ovaries no longer pro
duce it, in order to prevent certain uncomfortable
symptoms of estrogen deficiency. (All women nor
mally stop producing estrogens, generally between
the ages of 45-50; this is called the menopause.)
2. To prevent symptoms of estrogen deficiency
when a woman’s ovaries have been removed sur
gically before the natural menopause.
3. To prevent pregnancy. (Estrogens are given
along with a progestogen, anotherfemale hormone;
these combinations are called oral contraceptives

or birth control pills. Patient labeling is available to women taking oral contraceptives and they will not be discussed in this leaflet.)
4. To treat certain cancers in men (cancer of the
prostate or breast) and in women (certain cancers
of the breast when they occur more than 5 years
after menopause).
5. To prevent painful swelling of the breasts after
pregnancy in women who choose not to nurse
their babies,
THERE IS NO PROPER USE OF ESTROGENS IN A PREGNANT WOMAN.
ESTROGENS IN THE MENOPAUSE
In the natural course of their lives, all women eventually experience a fall in estrogen production. This usually occurs between ages 45 and 50 but may occur earlier or later. Sometimes the ovaries may need to be removed before natural menopause by an operation, producing a “surgical menopause.”
When the amount of estrogen in the blood begins to decrease many women may develop typical symptoms: Feelings of warmth in the face, neck, and chest or sudden intense episodes of heat and sweating throughout the body (called “hot flashes” or “hot flushes”). These symptoms are sometimes very uncomfortable. A few women eventually develop changes in the vagina (called “atrophic vaginitis”) which cause discomfort, especially during intercourse.
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gens are used and also seems to be greater when larger doses are taken. For this reason it is important to take the lowest dose of estrogen that will control symptoms and to take it only as long as it is needed. If estrogens are needed for longer periods of time, your doctor will want to reevaluate your need for estrogens at least every six months. Women_ using estrogens should report any irregular vaginal bleeding to their doctors; such bleeding may be of no importance, but it can be an early warning of cancer of the uterus. If you have undiagnosed vaginal bleeding, you should not use estrogens until a diagnosis is made and you are certain there is no cancer of the uterus.
2. Other possible cancers. Estrogens can cause
development of other tumors in animals, such as
tumors of the breast, cervix, vagina, or liver, when
given for a long time. At present there is no good
evidence that women using estrogens in the meno
pause have an increased risk of such tumors, but
there is no way yet to be sure they do not. This is a
further reason to use estrogens only when clearly
needed. While you are taking estrogens, it is im
portant that you go to your doctor at least once a
year to check on your uterus, cervix, vagina, and
breasts. Also, if members of your family have had
breast cancer or if you have breast nodules or
abnormal mamrnograms (breast x-rays), your
doctor will want to carry out especially careful
examination of your breasts.
3. Gall bladder disease. Women who use estro
gens after menopause are about 2-1/2 times as
likely to develop gall bladder disease needing sur
gery as women who do not use estrogens. Birth
control pills have a similar effect.
4. Abnormal blood clotting. Oral contraceptives
increase the risk of blood clotting in various parts
of the body. This can result in a stroke (if the clot
is in the brain), a heart attack (clot in a blood vessel
of the heart), or a pulmonary embolus (a clot which
forms in the legs or pelvis, then breaks off and
travels to the lungs). Any of these can be fatal.
At this time use of estrogens in the menopause is not known to cause such blood clotting, but this has not been fully studied and there could still prove to be such a risk. It is recommended that if you have had a heart attack, angina, or stroke, or if you have had clotting in the legs or lungs associated with use of estrogens or birth control pills, you should not use estrogens (unless they are being used to treat cancer of the breast or prostate).
The larger doses of estrogen used to prevent swelling of the breasts after pregnancy have been reported to cause clotting in the legs and lungs.drugsdcom drugxscom drugsxcom drugzscom drugszcom drugsxcom drugscxom drugsdcom drugscdom drugsfcom drugscfom drugsvcom drugscvom drugsciom drugscoim drugsc9om drugsco9m drugsc0om drugsco0m drugscpom drugscopm drugsclom drugscolm drugsckom drugscokm drugsconm drugscomn drugscojm drugscomj drugscokm drugscomk

INSTRUCTIONS
Zyloprim is the trade name of Allopurinol. It is used for the treatment of gout and other conditions associated with .too much uric acid in the blood. For instance, after frequent use of diuretics, kidneys may tend to retain uric acid, eventually causing gout.
Follow the instructions on the prescription exactly. Do not lake a larger or smaller dose of the medicine than the prescription tells you to. Unless the prescription tells you otherwise, take Zyloprim after meals while the stomach is still full. You should drink 10 or more glasses of fluids daily so thar’fhe amount of urine produced each day will be two quarts or .more. Follow your prescribed diet faithfully.
Take all the medicine prescribed, even if you feel much better before you have taken all of it. If you have an adverse reaction, stop using the medicine and contact your doctor.

PRECAUTIONS
Using medicines together may some-
times cause unfavorable reactions. So
tell your doctor about any medicine you are taking now (including drugs you buy without prescription). It is especially important for your physician to know if you are taking anticoagulants.
You should not take iron while you are taking Zyloprim. Do not give any of this medicine to anyone else. If you are pregnant or think you might be pregnant, tell your doctor before you start taking Zyloprim, If you are a nursing mother, ask for special instructions.
*».
POSSIBLE SIDE EFFECTS

Effective medicine may cause “side effects” in some people. New symptoms may be caused by the medicine, the original disorder, or a new illness that may develop. Most people experience few or no side effects, and those that do happen tend to disappear in time after you stop using the medicine or when your body adjusts to it.
It is possible that Zyloprim may cause drowsiness, skin rashes, nausea or diarrhea. If you should develop any of these symptoms to an uncomfort-

able degree or think that the medicine is bothering you in some other way, stop taking it temporarily and notify your doctor. He may decide to change your’dosage schedule or discontinue the medicine.
YOUR ACTIVITIES OF DAILY LIVING
This medicine should not cause any change in your degree of mental alertness or in the efficiency of your reflexes, so the medicine itself should not cause you to change your usual daily activities.

STORAGE
Keep this medicine in a tightly closed container in a dry, cool place away from heat or direct sunlight and out of reach of children. Don’t use the bathroom cabinet because humidity is high there. If you store medicine in the refrigerator, do not let it freeze. Don’t save left-over medicine to “use later.” Discard it on the expiration date shown on the container, but do so in a way that will protect children or pets—flush down the toilet, for example.
REFILLS
All refills must be ordered by your doctor, either in the first prescription or later. Only the pharmacy that originally filled this prescription can refill it If you go elsewhere, you must have a new prescription. Call the pharmacist and order your refill by number; it can be ready when you go to pick it up. Use one pharmacy for the whole family if you can. That way a complete record of all your drugs can be kept and the pharmacist can communicate effectively with your doctor.

OVERDOSAGE & TREATMENT
It is very uniikely that this particular medication would be threatening to your life. Nevertheless, if someone accidentally or purposefully takes an amount greatly exceeding the dosage prescribed, call your doctor or the nearest Poison Control Center or hospital emergency room to request specific instructions. Phone
numbers:

Please post this information sheet in a conspicuous place close to where you store the medicine so you will see it frequently and can refer to it easily. To avoid future confusion with other medicines, discard this sheet when you finish the course of treatment requiring the use of this drug.

INSTRUCTIONS
Wans is the trade name of a mixture of pyrilamine maleate and pentobarbital sodium. It is used for the symptomatic treatment of nausea and vomiting. It is intended as an aid to reduce troublesome symptoms; it is not expected to cure any disorder. Do not use this medicine if you know you are allergic to either of its components.
Follow the instructions on the prescription exactly. Do not use any more or any less of the medicine than the prescription tells you to. This medicine is given rectafly. Remove the wrapper and moisten with a little water; insert gently into the rectum with a finger.
In many cases it will not be necessary or desirable for you to use all of this medicine. Follow your doctor’s instructions exactly. If the symptoms for which the medicine was prescribed improve, or if you have any adverse reactions that you think may be caused by the medicine, stop using it and contact your doctor for further instructions.

PRECAUTIONS
Using medicines together may sometimes cause unfavorable reactions. So tell your doctor about any medicine you are taking now (including drugs you buy with out prescription).
Do not use Wans if you have porphyria, severe liver disease or an acute head injury. Not recommended for use in infants under 6 months of age. Do not take alcoholic beverages, sedatives, tranquilizers or narcotics while you use this medicine.
Do not give any of this medicine to anyone else. If you have fever, an overactive thyroid gland, diabetes, or heart trouble, or if you are pregnant or think you might be pregnant, tell your doctor before you start using Wans.
* ** POSSIBLE SIDE EFFECTS
Effective medicine may cause “side effects” in some people. New symptoms may be caused by the medicine, the original disorder, or a new illness that may develop. Most people experience few or no side effects, and those that do happen tend to disappear in time after you stop using the medicine or when your body adjusts to it.
It is possible that Wans may cause confusion, delirium, lassitude, dizziness, nausea, vomiting, diarrhea, skin rashes, fatigue, tremor, muscle weakness, dryness of the nose, mouth or throat, ringing in the ears, blurred vision, urinary retention, insomnia or convulsions. If you should develop any of these symptoms to an uncomfortable degree or think that the medicine is bothering you in some other way, stop using it temporarily and notify your doctor. He may decide to change your dosage schedule or discontinue the medicine.

‘WARNING: HABIT-FORMING
YOUR ACTIVITIES OF DAILY LIVING
Until you experience how this medicine affects you, don’t drive a car or other vehicle, don’t work around dangerous machinery, don “I climb .ladders, and don’t work in high places. Especially follow these restrictions if you also drink any beverage with alcohol, or.take any other medicine that might affect your alertness or reflexes, such as tranquilizers, sedatives, anti-histamines, medicine for pain, and others.
STORAGE
Keep this medicine in a tightly closed container in a dry, cool place away from heat or direct sunlight and out of reach of children. Don’t use the bathroom cabinet because humidity is high there. If you store medicine in the refrigerator, do not let it freeze. Don’t save left-over medicine to “use later.” Discard it on the expiration date shown on the container, but do so in a way that will protect children or pets-flush down the toilet, for example.

REFILLS
All refills must be ordered by your doctor, either in the ‘first prescription or later. Only the pharmacy that originally filled this prescription can refill it. If you go elsewhere, you must have a new prescription. Call the pharmacist and order your refill by number; it can be ready when you go to pick it up. Use one pharmacy for the whole family if you can. That way a complete record of all your drugs can be kept and the pharmacist can communicate effectively with your doctor.
J OVERDOSAGE: WHAT TO DO
CALL THE DOCTOR OR ^___^ FOR HELP OR AN AMBULANCE. Then
give FIRST AID! The patient is unconscious or very drowsy: (a)
Not breathing: Try mouth-to-mouth breathing.
(b) No heart beat: Use cardiac massage if you know
how; hit the breast-bone hard with your fist.
(c) Don’t try to make him vomit, (d) If you can’t get
help, take the patient to the nearest qualified
Emergency facility.
The patient is alert: (a) Give milk {undiluted evaporated milk is best), (b) Try to induce vomiting with Syrup of Ipecac’ if available; otherwise push your finger far back in his throat. Try to save the vornit for tests. Next, give Activated Charcoal.” (c) If no professional help can be found, don’t wait. Take the patient to the nearest Emergency facility.
ALWAYS BRING ANY REMAINING MEDICINE AND EMPTY BOTTLES!
“Syrup of Ipecac and Activated Charcoal wild instructions should be in every household for treatment of medication accidents. Ask your doclor for Ihem.

Please post this information sheet in a conspicuous place close to where you store the medicine so you will see it frequently and can refer to it easily. To avoid future confusion with other medicines, discard this sheet when you finish the course of treatment requiring the use of this drug.

INSTRUCTIONS
Wyanoids-HC is the trade name of a mixture of the components listed above. It is used for the treatment of pain and itching associated with minor anorectal disorders. It is intended as an aid to reduce troublesome symptoms; it is not expected to cure any disorder.
Follow the instructions on the prescription exactly. Do not use any more or any less of the medicine than the prescription tells you to. Use one suppository in the morning and at bedtime for three to six days or until the inflammation subsides. Unwrap the suppository, moisten it and gently push it up into the rectum with your finger.
In many cases it will not be necessary or desirable for you to use a/I of this medicine. Follow your doctor’s instructions exactly. If the symptoms for which the medicine was prescribed improve, or if you have any adverse reactions that you think may be caused by the medicine, stop using it and contact your doctor for further instructions.

way, stop using it temporarily and notify your doctor. He may decide to change your dosage or discontinue the medicine.
YOUR ACTIVITIES OF DAILY LIVING
This medicine should not cause any change in your degree of mental alertness or in the efficiency of your reflexes, so the medicine itself should not cause you to change your usual daily activities.
STORAGE
Keep this medicine in a tightly closed container in a dry, cool place away from heat or direct sunlight and out of reach of children. Don’t use the bathroom cabinet because humidity is high there. If you store medicine in the refrigerator, do not let it freeze. Don’t save left-over medicine to “use later.” Discard it on the expiration date shown on the container, but do so in a way that will protect children or pets —flush down the toilet, for example.

PRECAUTIONS
Using medicines together may some-times cause unfavorable reactions. So tell your doctor about any medicine you are taking now (including drugs you buy without prescription). Do not use this medicine if you know you are allergic to any of its components. Do not give any of this medicine to anyone else.
**» POSSIBLE SIDE EFFECTS
Effective medicine may cause “side ef-
fects” in some people. New symptoms
may be caused by the medicine, the original disorder, or a new illness that may develop. Most people experience few or no side effects, and those that do happen tend to disappear in time after you stop using the medicine or when your body adjusts to it.
It is possible that Wyanoids-HC may cause symptoms of taking hydrocortisone internally if you continue using the medicine too long. If you should develop new symptoms to an uncomfortable degree or think that the medicine is bothering you in any

REFILLS
All refills must be ordered by your doctor, either in the first prescription or later. Only the pharmacy that originally filled this prescription can refill it. If you go elsewhere, you must have a new prescription. Call the pharmacist and order your refill by number; it can be ready when you go to pick it up. Use one pharmacy for the whole family if you can. That way a complete record of all your drugs can be kept and the pharmacist can communicate effectively with your doctor.
OVERDOSAGE & TREATMENT
It is very unlikely that this particular medication would be threatening to your life. Nevertheless, if someone accidentally or purposefully takes an amount greatly exceeding the dosage prescribed, call your doctor or the nearest Poison Control Center or hospital emergency room to request specific instructions. Phone
numbers:

Please post this information sheet in a conspicuous place close to where you store the medicine so you will see it frequently andean refer to it easily. To avoid future confusion with other medicines, discard this sheet when you finish the course of treatment requiring the use of this drug.

INSTRUCTIONS
Vitamin B is another name for cyano-cobalamin. It is used for the treatment of Vitamin B,2 deficiencies,
Follow the instructions on the prescription exactly. Do not inject any more or any less of the medicine than the prescription tells you to. It is most important that you understand that you should receive Vitamin B,., at regular intervals for the rest of your life to prevent irreversible damage to the nerve cells in your body.
Take all the medicine prescribed, even if you feel much better before you have taken all of it. If you have an adverse reaction, stop using the medicine and contact your doctor.

PRECAUTIONS
Using medicines together may some-
times cause unfavorable reactions. So
tell your doctor about any medicine you are taking now (including drugs you buy without prescription). Vitamin B,2 tablets or capsules taken by mouth are not reliable for treating problems needing Vitamin B,2. You will need to continue the injections at regular intervals indefinitely.
POSSIBLE SIDE EFFECTS
There are no known toxic effects or known side effects.
YOUR ACTIVITIES OF DAILY LIVING
This medicine should not cause any change in your degree of mental alert-
ness or in the efficiency of your reflexes, so the

medicine itself should not cause you to change your usual daily activities.

STORAGE
Keep this medicine in a tightly closed container in a dry, cool place away from heat or direct sunlight and out of reach of children. Don’t use the bathroom cabinet because humidity is high there. If you store medicine in the refrigerator, do not let it freeze. Don’t save left-over medicine to “use later.” Discard it on the expiration date shown on the container, but do so in a way that will protect children or pets-flush down the toilet, for example.
REFILLS
All refills must be ordered by your doctor, either in the first prescription or later. Only the pharmacy that originally filled this prescription can refill it. If you go elsewhere, you must have a new prescription. Call the pharmacist and order your refill by number; it can be ready when you go to pick it up. Use one pharmacy for the whole family if you can. That way a complete record of all your drugs can be kept and the pharmacist can communicate effectively with your doctor,

OVERDOSAGE & TREATMENT
numbers:
It is very unlikely that this particular medication would be threatening to your life. Nevertheless, if someone accidentally or purposefully takes an amount greatly exceeding the dosage prescribed, call your doctor or the nearest Poison Control Center or hospital emergency room to request specific instructions. Phone

Please post this information sheet in a conspicuous place close to where you store the medicine so you will see it frequently and can refer to it easily. To avoid future confusion with other medicines, discard this sheet when you finish the course of treatment requiring the use of this drug.

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